E3 Ligand-Linker Conjugate 8( —— )

Catalog No. M13068 CAS No. 1957235-74-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

E3 Ligand-Linker Conjugate 8
Note

Research use only, not for human use.
Brief Description

An E3 ligase ligand-linker conjugate for PROTAC.
Description

An E3 ligase ligand-linker conjugate for PROTAC.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

——
Synonyms

——
Pathway

PROTACs
Target

E3 Ligase Ligand
Recptor

E3 Ligase Ligand
Research Area

Other Indications
Indication

——

CAS Number

1957235-74-3
Formula Weight

462.459
Molecular Formula

C21H26N4O8
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCN
Chemical Name

N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

1. Lohbeck J, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262.

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